Week Section Civetta Chapter Module Questions Article
1 General  71:  The Surgical Patient Surgical Issues in Critical Care Medicine Miscellaneous 54 Prasad. A Decade of Reversal: An Analysis of 146 Contradicted Medical Practices. Mayo Clinic Proceedings 2013;88(8):790-798
2 Physiology 41:  Fluids and Electrolytes Medical Errors Lytes 28 Finfer. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004;350(22):2247-56
3 Physiology 42:  Blood Gas Analysis and Acid Base Dz Ethics in the Intensive Care Unit Miscellaneous 46 Ely.  Effect on the Duration of Mechanical Ventilation Identifying Patients Capable of Breathing Spontaneously.  N Engl J Med 1996; 335:1864-1869
4 Physiology 44:  Lung Structure and Function Principles of Transplantation Miscellaneous 43 Stinger. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma 2008, 64(2 Supp):S79-S85.
5 Physiology 45:  Cardiovascular System Shock Cardiovascular 12 Determann. Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care 2010;14(1):R1
6 Physiology 40:  Anesthesia in the ICU Muscular System  Anesthesia 2 Kress. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-7
7 Monitoring 16:  Invasive Pressure Monitoring Critical Care for Older Adults Cardiovascular 10 Jakob. Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation: Two Randomized Controlled Trials. JAMA 2012;307(11):1151-1160
8 Monitoring 18:  Hemodynamic Monitoring - arterial, PA Perioperative Care of the Cardiac Surgery Patient Cardiovascular 17 Harvey. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet 2006;366:472-477
9 Monitoring 19:  Monitoring Tissue Perfusion and Oxygenation Arterial Blood Gas Interpretation Cardiovascular 5 Ely. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU).  Crit Care Med. 2001 Jul;29(7):1370-9.
10 Monitoring 23:  Echocardiography Ultrasound Guided CVP Line Placement Cardiovascular 15 Yang.  A Prospective Study of Indexes Predicting the Outcome of Trials of Weaning from Mechanical Ventilation.  N Engl J Med 1991; 324:1445-1450
11 CV 118:  Chest Pain and ACS in SICU Cardiogenic Shock, Acute Coronary Syndrome and Congestive Heart Failure Cardiovascular 14 Chastre. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 2003; 290: 2588- 2598
12 CV 121:  Evaluation and Mgmt of Heart Failure Arrhythmias - Part 1 Cardiovascular 11 Bernard. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. N Engl J Med 2002; 346:557-563
13 CV 124:  Cardiac Dysrhythmias Arrhythmias - Part 2 Cardiovascular 6 Nielsen. Targeted Temperature Management at 33C versus 36C after Cardiac Arrest. N Engl J Med 2013;369:2197-2206
14 CV 126:  Acute Hypertension Mgmt in ICU Arrhythmias - Part 3 Cardiovascular 9 Ferrara.  Flat Inferior Vena Cava: Indicator of Poor Prognosis in Trauma and Acute Care Surgery Patient.  Am Surg 2012 Dec; Vol. 78 (12), pp. 1396-8.
15 CV 127:  Heart-Lung Interactions Therapeutic Hypothermia and Post-Resuscitation Care of the Cardiac Arrest Survivor Cardiovascular 16 Villanueva. Transfusion Strategies for Acute Upper Gastrointestinal Bleeding. N Engl J Med 2013;368:11-21
16 Respiratory 128:  Anatomy of Mechanical Ventilation Mechanical Ventilation – Basics - 1 Pulmonary 61 Girard. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial). Lancet 
17 Respiratory 129:  Noninvasive Ventilatory Support Modes Mechanical Ventilation Basics - 2 Pulmonary 63 Andersen. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med 2003;349(8):733-42
18 Respiratory 130:  Invasive Ventilatory Support Modes Initial Assessment and Resuscitation of the Severely Burned Patient Pulmonary 65 Douketis.  Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation.  N Engl J Med 2015; 373:823-833
19 Respiratory 131:  Bedside Interpretation of Ventilatory Waveforms Critical Temperature Related Illnesses Pulmonary 65 Papazian. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363:1107-1116
20 Respiratory 132:  Weaning from Mechanical Ventilation Skeletal System Pulmonary 66 Drakulovic. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 1999;354(9193):1851Ð1858
21 Respiratory 136:  ALI and ARDS Acute Lung Injury and ARDS Pulmonary 67 The Acute Respiratory Distress Syndrome Network. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. N Engl J Med 2000; 342:1301-1308
22 Respiratory 139:  Aspiration Critical Care in Pregnancy Miscellaneous 40 GuŽrin. Prone Positioning in Severe Acute Respiratory Distress Syndrome (PROSEVA). New Engl J Med 2013; 368:2159-2168
23 Respiratory 141:  Acute Respiratory Failure with COPD Obstetrics in ICU Miscellaneous 52 Umpierrez.  Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial).  Diabetes Care. 2007 Sep;30(9):2181-6. Epub 2007 May 18.
24 Respiratory 142:  Pulmonary Embolism Pulmonary Emboli Cardiovascular 13 Meyer. Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism (PEITHO study). N Engl J Med 2014;370:1402-1411
25 Respiratory 37:  Bronchoscopy Airway Management in the Emergency Department & ICU Ethics 75 Bouadma. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomized controlled trial. Lancet. 2010;375:463-474.
26 Respiratory 38:  Airway Mgmt Airway Management in the Emergency Department & ICU Anesthesia 1 Annane. Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults. JAMA 2009;301(22):2362-2375
27 ID 104:  Role of Abx in Mgmt of Serious HAI Principles of Treating Infectious Illnesses in Critical Care: Focus on Antibiotic Resistance and Choice  ID 39 Russell. Vasopressin versus norepinephrine infusion in patients with septic shock (VASST). NEJM 2008;358:877-87
28 ID 105:  Approach to Febrile ICU Patient Sepsis and Septic Shock: Old Concepts, New Precepts ID 38 Asfar. High versus Low Blood-Pressure Target in Patients with Septic Shock (SEPSISPAM study). New Engl J Med 2014;370:1583-1593
29 ID 106:  Surgical Infections Surviving Sepsis Campaign: Guidelines for Management of Severe Sepsis ID 38 The ProCESS Investigators. A Randomized Trial of Protocol-Based Care for Early Septic Shock (ProCESS study). New Engl J Med 2014;epublished March 18th
30 ID 108:  Neurologic Infections Surviving Sepsis Campaign: Guidelines for Management of Severe Sepsis Neuro 57 Kumar. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009; 136(5):1237-1248.
31 ID 110:  Catheter-Related Bloodstream Infections Surviving Sepsis Campaign: Guidelines for Management of Severe Sepsis Critical Care Midterm Kumar. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34(6): 1589-1596
32 ID 111:  Respiratory Infections Septic Shock Critical Care Midterm Drakulovic. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 1999;354(9193):1851Ð1858
33 ID 113:  Catheter-Associated Urinary Tract Infections in ICU Septic Shock Critical Care Midterm Chastre. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 2003; 290: 2588- 2598
34 ID 114:  Fungal and Viral Infections Septic Shock Critical Care Midterm Harris. Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial. JAMA 2013;epublished October 4th
35 Neuro 147:  Altered Conciousness and Coma in ICU Neurologic and Neurosurgical Emergencies in the ICU Neuro 58 Allen. Cerebral Arterial Spasm Ð A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage. N Engl J Med 1983; 308:619-624
36 Neuro 148:  Seizures and Status Epilepticus Neurologic and Neurosurgical Emergencies in the ICU Neuro 59 Chesnut. A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury. New Engl J Med 2012;367:2471-2481
37 GI 152:  Upper GI Bleeding Hemostasis Problems in Critical Illness GI 31 Schweickert. Early physical and occupational therapy in mechanically ventilated, critically ill patients: A randomised controlled trial. Lancet 2009; 373:1874Ð1882 
38 GI 153:  Approach to LGIB Hemostasis Problems in Critical Illness GI 32 Reignier. Effect of Not Monitoring Residual Gastric Volume on Risk of Ventilator-Associated Pneumonia in Adults Receiving Mechanical Ventilation and Early Enteral Feeding:  A Randomized Controlled Trial. JAMA 2013;309(3):249
39 GI 154:  Liver Failure - Acute and Chronic Critical Care Aspects of Chronic Hepatic Failure GI 33 Giacino.  Placebo-Controlled Trial of Amantadine for Severe Traumatic Brain Injury.  N Engl J Med 2012; 366:819-826
40 GI 155:  Pancreatic Disease Critical Care Aspects of Chronic Hepatic Failure GI 34 Cook. Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group.  N Engl J Med. 1994;330(6):377.
41 Nutrition 64:  Nutritional Issues Nutritional Support in the ICU Lytes 25 Casaer. Early versus Late Parenteral Nutrition in Critically Ill Adults. NEJM 2011;365:506-517
42 Renal 160:  Acute Renal Failure Acute Kidney Dysfunction in the ICU Lytes 27 Bellomo. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 2000;356:2139-43
43 Renal 161:  Renal Replacement Therapies Acute Kidney Dysfunction in the ICU Renal 68 Vinsonneau. Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: A multicentre randomised trial. Lancet 2006; 368:379-385
44 Heme 171:  Blood Transfusion Venous Thromboembolism in Intensive Care Medicine Heme Onc 36 Hebert. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999;340:409-17
45 Heme 172:  Antithrombolitic and Thrombolytic Therapy Venous Thromboembolism in Intensive Care Medicine Heme Onc 37 Geerts.  A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma.  N Engl J Med. 1996 Sep 5;335(10):701-7.
46 Heme 173:  Hematolotic Conditions in ICU Hemostasis Problems in Critical Illness Miscellaneous 41 CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376:23-32 
47 Endo 163:  Disordered Glucose Metabolism Endocrine Issues in Critical Illness Endocrine 21 NICE-SUGAR Study Investigators. Intensive versus Conventional Glucose Control in Critically Ill Patients. N Engl J Med 2009;360:1283-97
48 Pharm 62:  Pharmacologic Principals Applied Pharmacokinetics in the Adult Critically Ill Miscellaneous 51 Van den Berghe. Intensive Insulin Therapy in Critically Ill Patients. N Engl J Med 2001;345:1359-67
49 Pharm 63:  Sedation and Neuromuscular Blockade Sedation, Analgesia & Neuromuscular Blockade in the Adult ICU  Miscellaneous 50 Str�m. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 2010;375(9713):475-480
50 Pharm 67:  Substance Abuse, Withdrawl, Poisoning & Toxicology Sedation, Analgesia & Neuromuscular Blockade in the Adult ICU  Miscellaneous 56 Pandharipande. Long-Term Cognitive Impairment after Critical Illness. N Engl J Med 2013;369:1306-1316

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